Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon.

ABSTRACT:

Background

Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is known to be expressed only in monocytes. However, its expression in situ has not yet been studied.

Aims

To analyse the tissue distribution of CARD15 and identify cells producing CARD15 in samples of colon from patients with Crohn's disease and control subjects.

Patients and methods

We analysed CARD15 gene expression in surgical specimens of colon from eight children with Crohn's disease and nine controls by immunohistochemistry, in situ hybridisation, and

SUBMITTER: Berrebi D 

PROVIDER: S-EPMC1773666 | biostudies-literature | 2003 Jun

REPOSITORIES: biostudies-literature