Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin.

ABSTRACT:

Background/aims

The gastric peptide ghrelin, an endogenous ligand for growth-hormone secretagogue receptor, has two major molecular forms: acylated ghrelin and desacyl ghrelin. Acylated ghrelin induces a positive energy balance, while desacyl ghrelin has been reported to be devoid of any endocrine activities. The authors examined the effects of desacyl ghrelin on energy balance.

Methods

The authors measured food intake, gastric emptying, c-Fos expression in the hypothalamus, and gene expression of hypothalamic neuropeptides in mice after administration of desacyl ghrelin. To explore the effects of long term overexpression of desacyl ghrelin, transgenic mice that overexpressed desacyl ghrelin were created.

Results

Administration of desacyl ghrelin decreased food intake

SUBMITTER: Asakawa A 

PROVIDER: S-EPMC1774379 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature