Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid.

ABSTRACT:

Background and aims

There are epidemiological, morphological, and molecular differences between normal mucosa as well as between adenocarcinomas of the right and left side of the large bowel. The aim of this study was to investigate differences in gene expression.

Methods

Oligonucleotide microarrays (GeneChip) were used to compare gene expression in 45 single samples from normal mucosa and sporadic colorectal carcinomas (Dukes' B and C) of the caecum compared with the sigmoid and rectosigmoid. Findings were validated by real time polymerase chain reaction.

Results

Fifty eight genes were found to be differentially expressed between the normal mucosa of the caecum and the sigmoid and rectosigmoid (p<0.01), including pS2, S100P, and a sialyltransferase, all being express

SUBMITTER: Birkenkamp-Demtroder K 

PROVIDER: S-EPMC1774427 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature