Homeostatic regulation of zinc transporters in the human small intestine by dietary zinc supplementation.

ABSTRACT:

Background

The role of intestinal transporter regulation in optimising nutrient absorption has been studied extensively in rodent and cell line models but not in human subjects.

Aims

The aim of the present study was to investigate the response in vivo of zinc transporters in the human enterocyte to dietary zinc supplementation.

Subjects

Eighteen patients who had previously undergone ileostomy, all free of any symptoms of inflammatory bowel disease.

Methods

Subjects took a daily zinc supplement of 25 mg for 14 days in a double blind, placebo controlled, crossover trial. The effect of the supplement on expression in ileal biopsies of the zinc transporters SLC30A1, SLC30A4, SLC30A5, SLC39A1, SLC39A4, and metallothionein was measured by reverse transcription-polyme

SUBMITTER: Cragg RA 

PROVIDER: S-EPMC1774437 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature