Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis.

ABSTRACT:

Background

Antinuclear antibodies (ANA) giving a rim-like/membranous (RL/M) or a multiple nuclear dot (MND) pattern are highly specific for primary biliary cirrhosis (PBC). Aim and

Subjects

To assess the prevalence of PBC specific ANAs, their Ig isotype, and their clinical significance in 90 PBC patients from Greece and Spain. Twenty eight patients with chronic hepatitis C, 23 patients with systemic lupus erythematosus, and 17 healthy subjects were studied as controls.

Methods

PBC specific ANA reactivity was tested by indirect immunofluorescence using HEp2 cells as substrate and individual Ig class (IgG, IgA, IgM) and IgG subclass (IgG1, IgG2, IgG3, IgG4) specific antisera as revealing reagents.

Results

Fourteen of 90 (15.6%) PBC patients had PBC specific ANA r

SUBMITTER: Rigopoulou EI 

PROVIDER: S-EPMC1774444 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature