Reparative properties of a commercial fish protein hydrolysate preparation.

ABSTRACT:

Background

A partially hydrolysed and dried product of pacific whiting fish is currently marketed as a health food supplement to support "intestinal health". However, there has been only limited scientific study regarding its true biological activity.

Aims

We therefore tested its efficacy in a variety of models of epithelial injury and repair.

Methods

Effects on proliferation were determined using [(3)H] thymidine incorporation into epithelial rat intestinal RIE-1 and human colonic HT29 cells. Effects on restitution (cell migration) were analysed using wounded HT29 monolayers and its ability to influence gastric injury analysed using a rat indomethacin restraint model. Partial characterisation of bioactive agents was performed using mass spectroscopy, high pressure li

SUBMITTER: Fitzgerald AJ 

PROVIDER: S-EPMC1774533 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature