Yeast genomic expression patterns in response to low-shear modeled microgravity.

ABSTRACT:

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The low-shear microgravity environment, modeled by rotating suspension culture bioreactors called high aspect ratio vessels (HARVs), allows investigation in ground-based studies of the effects of microgravity on eukaryotic cells and provides insights into the impact of space flight on cellular physiology. We have previously demonstrated that low-shear modeled microgravity (LSMMG) causes significant phenotypic changes of a select group of Saccharomyces cerevisiae genes associated with the establishment of cell polarity, bipolar budding, and cell separation. However, the mechanisms cells utilize to sense and respond to microgravity and the fundamental gene expression changes that occur are largely unknown. In this study, we examined the global transcriptional response of y

SUBMITTER: Sheehan KB 

PROVIDER: S-EPMC1774566 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature