Ghrelin treatment reverses the reduction in weight gain and body fat in gastrectomised mice.

ABSTRACT:

Background and aims

The gastric hormone ghrelin has been reported to stimulate food intake, increase weight gain, and cause obesity but its precise physiological role remains unclear. We investigated the long term effects of gastrectomy evoked ghrelin deficiency and of daily ghrelin injections on daily food intake, body weight, fat mass, lean body mass, and bone mass in mice.

Methods

Ghrelin was given by subcutaneous injections (12 nmol/mouse once daily) for eight weeks to young female mice subjected to gastrectomy or sham operation one week previously.

Results

Gastrectomy reduced plasma concentrations of total ghrelin (octanoylated and des-octanoylated) and active (octanoylated) ghrelin by approximately 80%. Immediately after injection of ghrelin, the plasma concentr

SUBMITTER: Dornonville de la Cour C 

PROVIDER: S-EPMC1774616 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature