DLG5 variants do not influence susceptibility to inflammatory bowel disease in the Scottish population.

ABSTRACT:

Introduction

Recent data have suggested that specific haplotypic variants of the DLG5 gene on chromosome 10q23 may be associated with susceptibility to inflammatory bowel disease (IBD) in Germany. Haplotype D, notably characterised by the presence of a G-->A substitution at nucleotide 113, was associated with susceptibility to Crohn's disease (CD) whereas an extended haplotype A conferred protection.

Aims

Association of DLG5 haplotypic variants with disease susceptibility, genotype-phenotype relationships, and epistasis with CARD15 was investigated in the Scottish population.

Patients and methods

A total of 374 CD, 305 ulcerative colitis (UC), and 294 healthy controls (HC) were studied. Genotyping for the variants rs1248696 (113A, representing haplotype D) and the sin

SUBMITTER: Noble CL 

PROVIDER: S-EPMC1774698 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature