Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.

ABSTRACT:

Background and aims

Recent data suggest identification of causal genetic variants for inflammatory bowel disease in the DLG5 gene and in the organic cation transporter (OCTN) cluster, both situated in previously described linkage regions.

Patients and methods

The polymorphisms in DLG5 (113 G-->A, 4136 C-->A, and DLG5_e26), SLC22A4 (1672 C-->T), and SLC22A5 (-207 G-->C) were assessed in 625 patients with Crohn's disease (CD), 363 patients with ulcerative colitis (UC), and 1012 healthy controls. Association with disease susceptibility, clinical phenotypes, and possible genetic interactions of these polymorphisms with disease associated CARD15/NOD2 mutations was analysed.

Results

No significant association of DLG5 polymorphisms with CD or UC was observed. Homozygosity fo

SUBMITTER: Torok HP 

PROVIDER: S-EPMC1774699 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature