Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease.

ABSTRACT:

Background

Osteoporosis is an important cause of morbidity in patients with Crohn's disease. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetic factors have been implicated in other populations of patients with osteoporosis.

Aim

To investigate the influence of interleukin 6 (IL-6), collagen type 1alpha1 (COL1A1), and vitamin D receptor gene (VDR) single nucleotide polymorphisms (SNP) on BMD in patients with Crohn's disease.

Patients

A cohort of 245 well characterised patients with Crohn's disease were recruited from the inflammatory bowel disease register at the Freeman Hospital and Royal Victoria Infirmary, Newcastle upon Tyne, and the Queen Elizabeth Hospital, Gateshead, UK.

Methods

Patients were genotyped for IL-6 C-

SUBMITTER: Todhunter CE 

PROVIDER: S-EPMC1774753 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature