Reduced expression of epidermal growth factor receptor related protein in gastric cancer.

ABSTRACT:

Objectives

The recently cloned epidermal growth factor receptor related protein (ERRP) has been proposed to be a negative regulator of the epidermal growth factor receptor (EGFR). Because of the causal involvement of EGFR and its ligands in gastric cancer growth, we investigated expression of ERRP and cell proliferation in human gastric cancer.

Methods

We examined ERRP expression and localisation in surgical specimens of gastric cancers from 47 patients versus non-malignant gastric mucosa and determined their relationship to cell proliferation and differentiation. We also examined expression of ERRP by western blotting in three different gastric cancer cell lines. To further determine the functional properties of ERRP, we examined the effect of ERRP on epidermal growth facto

SUBMITTER: Moon WS 

PROVIDER: S-EPMC1774858 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature