Family history and molecular features of children, adolescents, and young adults with colorectal carcinoma.

ABSTRACT:

Background

Colorectal cancer is extremely rare in childhood. Published case series reporting children and adolescents with colorectal cancer have not focused on the underlying genetic aspects of the tumour or genetic susceptibility of the families.

Aims

We examined a cohort of patients with early onset colorectal cancer to determine whether a specific genetic predisposition could be elucidated. In particular, we focused on whether DNA mismatch repair gene deficiency which causes hereditary non-polyposis colorectal cancer (HNPCC) could be elucidated.

Methods

Patients with colorectal cancer

SUBMITTER: Durno C 

PROVIDER: S-EPMC1774876 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature