Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis.

ABSTRACT: Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1% of the population worldwide. Previously, we showed that human T-cell leukemia virus type I-transgenic mice and interleukin-1 receptor antagonist-knockout mice develop autoimmunity and joint-specific inflammation that resembles human RA. To identify genes involved in the pathogenesis of arthritis, we analyzed the gene expression profiles of these animal models by using high-density oligonucleotide arrays. We found 1,467 genes that were differentially expressed from the normal control mice by greater than threefold in one of these animal models. The gene expression profiles of the two models correlated well. We extracted 554 genes whose expression significantly changed in both models, assuming that pathogenically i

SUBMITTER: Fujikado N 

PROVIDER: S-EPMC1779393 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature