Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis.

ABSTRACT: Although strong epidemiologic evidence suggests an important role for adaptive immunity in the pathogenesis of polyarticular juvenile rheumatoid arthritis (JRA), there remain many aspects of the disease that suggest equally important contributions of the innate immune system. We used gene expression arrays and computer modeling to examine the function in neutrophils of 25 children with polyarticular JRA. Computer analysis identified 712 genes that were differentially expressed between patients and healthy controls. Computer-assisted analysis of the differentially expressed genes demonstrated functional connections linked to both interleukin (IL)-8- and interferon-gamma (IFN-gamma)-regulated processes. Of special note is that the gene expression fingerprint of children with active JRA remai

SUBMITTER: Jarvis JN 

PROVIDER: S-EPMC1779452 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature