Predicting a local recurrence after breast-conserving therapy by gene expression profiling.

ABSTRACT:

Introduction

To tailor local treatment in breast cancer patients there is a need for predicting ipsilateral recurrences after breast-conserving therapy. After adequate treatment (excision with free margins and radiotherapy), young age and incompletely excised extensive intraductal component are predictors for local recurrence, but many local recurrences can still not be predicted. Here we have used gene expression profiling by microarray analysis to identify gene expression profiles that can help to predict local recurrence in individual patients.

Methods

By using previously established gene expression profiles with proven value in predicting metastasis-free and overall survival (wound-response signature, 70-gene prognosis profile and hypoxia-induced profile) and training to

SUBMITTER: Nuyten DS 

PROVIDER: S-EPMC1779489 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature