Classification of ductal carcinoma in situ by gene expression profiling.

ABSTRACT:

Introduction

Ductal carcinoma in situ (DCIS) is characterised by the intraductal proliferation of malignant epithelial cells. Several histological classification systems have been developed, but assessing the histological type/grade of DCIS lesions is still challenging, making treatment decisions based on these features difficult. To obtain insight in the molecular basis of the development of different types of DCIS and its progression to invasive breast cancer, we have studied differences in gene expression between different types of DCIS and between DCIS and invasive breast carcinomas.

Methods

Gene expression profiling using microarray analysis has been performed on 40 in situ and 40 invasive breast cancer cases.

Results

DCIS cases were classified as well- (n = 6),

SUBMITTER: Hannemann J 

PROVIDER: S-EPMC1779498 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature