Influence of metabolic network structure and function on enzyme evolution.

ABSTRACT:

Background

Most studies of molecular evolution are focused on individual genes and proteins. However, understanding the design principles and evolutionary properties of molecular networks requires a system-wide perspective. In the present work we connect molecular evolution on the gene level with system properties of a cellular metabolic network. In contrast to protein interaction networks, where several previous studies investigated the molecular evolution of proteins, metabolic networks have a relatively well-defined global function. The ability to consider fluxes in a metabolic network allows us to relate the functional role of each enzyme in a network to its rate of evolution.

Results

Our results, based on the yeast metabolic network, demonstrate that important evolution

SUBMITTER: Vitkup D 

PROVIDER: S-EPMC1779518 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature