PI3K signaling and miRNA expression during the response of quiescent human fibroblasts to distinct proliferative stimuli.

ABSTRACT:

Background

Serum treatment of quiescent human dermal fibroblasts induces proliferation, coupled with a complex physiological response that is indicative of their normal role in wound-healing. However, it is not known to what extent such complex transcriptional events are specific to a given cell type and signal, and how these global changes are coordinately regulated. We have profiled the global transcriptional program of human fibroblasts from two different tissue sources to distinct growth stimuli, and identified a striking conservation in their gene-expression signatures.

Results

We found that the wound-healing program of gene expression was not specific to the response of dermal fibroblasts to serum but was regulated more broadly. However, there were specific differences

SUBMITTER: Gu J 

PROVIDER: S-EPMC1779520 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature