Evolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence.

ABSTRACT:

Background

Despite the recent completion of the chimpanzee genome project, few functionally significant sequence differences between humans and chimpanzees have thus far been identified. Alteration in transcriptional regulatory mechanisms represents an important platform for evolutionary change, suggesting that a significant proportion of functional human-chimpanzee sequence differences may affect regulatory elements.

Results

To explore this hypothesis, we performed genome-wide identification of conserved candidate transcription-factor binding sites that have evolved since the divergence of humans and chimpanzees. Analysis of candidate transcription-factor binding sites conserved between mouse and chimpanzee yet absent in human indicated that loss of candidate transcription-

SUBMITTER: Donaldson IJ 

PROVIDER: S-EPMC1779530 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature