What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?

ABSTRACT:

Background

Most proteins interact with only a few other proteins while a small number of proteins (hubs) have many interaction partners. Hub proteins and non-hub proteins differ in several respects; however, understanding is not complete about what properties characterize the hubs and set them apart from proteins of low connectivity. Therefore, we have investigated what differentiates hubs from non-hubs and static hubs (party hubs) from dynamic hubs (date hubs) in the protein-protein interaction network of Saccharomyces cerevisiae.

Results

The many interactions of hub proteins can only partly be explained by bindings to similar proteins or domains. It is evident that domain repeats, which are associated with binding, are enriched in hubs. Moreover, there is an over represent

SUBMITTER: Ekman D 

PROVIDER: S-EPMC1779539 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature