Fine scale structural variants distinguish the genomes of Drosophila melanogaster and D. pseudoobscura.

ABSTRACT:

Background

A primary objective of comparative genomics is to identify genomic elements of functional significance that contribute to phenotypic diversity. Complex changes in genome structure (insertions, duplications, rearrangements, translocations) may be widespread, and have important effects on organismal diversity. Any survey of genomic variation is incomplete without an assessment of structural changes.

Results

We re-examine the genome sequences of the diverged species Drosophila melanogaster and D. pseudoobscura to identify fine-scale structural features that distinguish the genomes. We detect 95 large insertion/deletion events that occur within the introns of orthologous gene pairs, the majority of which represent insertion of transposable elements. We also identify 1

SUBMITTER: Macdonald SJ 

PROVIDER: S-EPMC1779558 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature