Design principles of molecular networks revealed by global comparisons and composite motifs.

ABSTRACT:

Background

Molecular networks are of current interest, particularly with the publication of many large-scale datasets. Previous analyses have focused on topologic structures of individual networks.

Results

Here, we present a global comparison of four basic molecular networks: regulatory, co-expression, interaction, and metabolic. In terms of overall topologic correlation--whether nearby proteins in one network are close in another--we find that the four are quite similar. However, focusing on the occurrence of local features, we introduce the concept of composite hubs, namely hubs shared by more than one network. We find that the three 'action' networks (metabolic, co-expression, and interaction) share the same scaffolding of hubs, whereas the regulatory network uses distinc

SUBMITTER: Yu H 

PROVIDER: S-EPMC1779570 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature