Shuffling of cis-regulatory elements is a pervasive feature of the vertebrate lineage.

ABSTRACT:

Background

All vertebrates share a remarkable degree of similarity in their development as well as in the basic functions of their cells. Despite this, attempts at unearthing genome-wide regulatory elements conserved throughout the vertebrate lineage using BLAST-like approaches have thus far detected noncoding conservation in only a few hundred genes, mostly associated with regulation of transcription and development.

Results

We used a unique combination of tools to obtain regional global-local alignments of orthologous loci. This approach takes into account shuffling of regulatory regions that are likely to occur over evolutionary distances greater than those separating mammalian genomes. This approach revealed one order of magnitude more vertebrate conserved elements than

SUBMITTER: Sanges R 

PROVIDER: S-EPMC1779573 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature