A genome-wide approach to identify genetic loci with a signature of natural selection in the Irish population.

ABSTRACT:

Background

In this study we present a single population test (Ewens-Waterson) applied in a genomic context to investigate the presence of recent positive selection in the Irish population. The Irish population is an interesting focus for the investigation of recent selection since several lines of evidence suggest that it may have a relatively undisturbed genetic heritage.

Results

We first identified outlier single nucleotide polymorphisms (SNPs), from previously published genome-wide data, with high FST branch specification in a European-American population. Eight of these were chosen for further analysis. Evidence for selective history was assessed using the Ewens-Watterson's statistic calculated using Irish genotypes of microsatellites flanking the eight outlier SNPs. Evi

SUBMITTER: Mattiangeli V 

PROVIDER: S-EPMC1779589 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature