Statistical assessment of the global regulatory role of histone acetylation in Saccharomyces cerevisiae.

ABSTRACT:

Background

Histone acetylation plays important but incompletely understood roles in gene regulation. A comprehensive understanding of the regulatory role of histone acetylation is difficult because many different histone acetylation patterns exist and their effects are confounded by other factors, such as the transcription factor binding sequence motif information and nucleosome occupancy.

Results

We analyzed recent genomewide histone acetylation data using a few complementary statistical models and tested the validity of a cumulative model in approximating the global regulatory effect of histone acetylation. Confounding effects due to transcription factor binding sequence information were estimated by using two independent motif-based algorithms followed by a variable selec

SUBMITTER: Yuan GC 

PROVIDER: S-EPMC1779595 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature