Evolutionarily new sequences expressed in tumors.

ABSTRACT:

Background

Earlier we suggested the concept of the positive evolutionary role of tumors. According to this concept, tumors provide conditions for the expression of evolutionarily new and/or sleeping genes in their cells. Thus, tumors are considered as evolutionary proving ground or reservoir of expression. To support this concept we have previously characterized in silico and experimentally a new class of human tumor-related transcribed sequences.

Results

In this article we describe results of further studies of previously described tumor-related sequences. The results of molecular phylogeny studies, Southern hybridization experiments and computational comparison with genomes of other species are presented.

Conclusion

These results suggest that these previously descri

SUBMITTER: Kozlov AP 

PROVIDER: S-EPMC1779766 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature