Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe.

ABSTRACT:

Background

The choice of a stem cell to divide symmetrically or asymmetrically has profound consequences for development and disease. Unregulated symmetric division promotes tumor formation, whereas inappropriate asymmetric division affects organ morphogenesis. Despite its importance, little is known about how spindle positioning is regulated. In some tissues cell fate appears to dictate the type of cell division, whereas in other tissues it is thought that stochastic variation in spindle position dictates subsequent sibling cell fate.

Results

Here we investigate the relationship between neural progenitor identity and spindle positioning in the Drosophila optic lobe. We use molecular markers and live imaging to show that there are two populations of progenitors in the optic

SUBMITTER: Egger B 

PROVIDER: S-EPMC1779784 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature