Effect of isoniazid prophylaxis on mortality and incidence of tuberculosis in children with HIV: randomised controlled trial.

ABSTRACT:

Objectives

To investigate the impact of isoniazid prophylaxis on mortality and incidence of tuberculosis in children with HIV.

Design

Two centre prospective double blind placebo controlled trial.

Participants

Children aged > or =8 weeks with HIV.

Interventions

Isoniazid or placebo given with co-trimoxazole either daily or three times a week.

Setting

Two tertiary healthcare centres in South Africa.

Main outcome measures

Mortality, incidence of tuberculosis, and adverse events.

Results

Data on 263 children (median age 24.7 months) were available when the data safety monitoring board recommended discontinuing the placebo arm; 132 (50%) were taking isoniazid. Median follow-up was 5.7 (interquartile range 2.0-9.7) months. Mortality was lower in

SUBMITTER: Zar HJ 

PROVIDER: S-EPMC1779846 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature