FoxD3 and Grg4 physically interact to repress transcription and induce mesoderm in Xenopus.

ABSTRACT: FoxD3 is a forkhead-related transcriptional regulator that is essential for multiple developmental processes in the vertebrate embryo, including neural crest development and maintenance of mammalian stem cell lineages. Recent results demonstrate a requirement for FoxD3 in Xenopus mesodermal development. In the gastrula, FoxD3 functions as a transcriptional repressor in the Spemann organizer to maintain the expression of Nodal-related members of the transforming growth factor-beta superfamily that induce dorsal mesoderm formation. Here we report that the function of FoxD3 in mesoderm induction is dependent on the recruitment of transcriptional corepressors of the TLE/Groucho family. Structure-function analyses indicate that the transcriptional repression and mesoderm induction activities of

SUBMITTER: Yaklichkin S 

PROVIDER: S-EPMC1780074 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature