The relationship between protein sequences and their gene ontology functions.

ABSTRACT:

Background

One main research challenge in the post-genomic era is to understand the relationship between protein sequences and their biological functions. In recent years, several automated annotation systems have been developed for the functional assignment of uncharacterized proteins. The underlying assumption of these systems is that similar sequences imply similar biological functions. However, it has been noted that matching sequences do not always infer similar functions.

Results

In this paper, we present the correlation between protein sequences and protein functions for the yeast proteome in the context of gene ontology. A novel measure is introduced to define the overall similarity between two protein sequences. The effects of the level as well as the size of a gene

SUBMITTER: Duan ZH 

PROVIDER: S-EPMC1780109 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature