Occurrence of protein structure elements in conserved sequence regions.

ABSTRACT:

Background

Conserved protein sequence regions are extremely useful for identifying and studying functionally and structurally important regions. By means of an integrated analysis of large-scale protein structure and sequence data, structural features of conserved protein sequence regions were identified.

Results

Helices and turns were found to be underrepresented in conserved regions, while strands were found to be overrepresented. Similar numbers of loops were found in conserved and random regions.

Conclusion

These results can be understood in light of the structural constraints on different secondary structure elements, and their role in protein structural stabilization and topology. Strands can tolerate fewer sequence changes and nonetheless keep their specific sh

SUBMITTER: Sitbon E 

PROVIDER: S-EPMC1781454 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature