Transcriptional profiling of the LPS induced NF-kappaB response in macrophages.

ABSTRACT:

Background

Exposure of macrophages to bacterial products such as lipopolysaccharide (LPS) results in activation of the NF-kappaB transcription factor, which orchestrates a gene expression programme that underpins the macrophage-dependent immune response. These changes include the induction or repression of a wide range of genes that regulate inflammation, cell proliferation, migration and cell survival. This process is tightly regulated and loss of control is associated with conditions such as septic shock, inflammatory diseases and cancer. To study this response, it is important to have in vitro model systems that reflect the behaviour of cells in vivo. In addition, it is necessary to understand the natural differences that can occur between individuals. In this report, we have in

SUBMITTER: Sharif O 

PROVIDER: S-EPMC1781469 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature