Jagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric duct.

ABSTRACT: Pronephros, a developmental model for adult mammalian kidneys (metanephros) and a functional kidney in early teleosts, consists of glomerulus, tubule, and duct. These structural and functional elements are responsible for different kidney functions, e.g., blood filtration, waste extraction, salt recovery, and water balance. During pronephros organogenesis, cell differentiation is a key step in generating different cell types in specific locations to accomplish designated functions. However, it is poorly understood what molecules regulate the differentiation of different cell types in different parts of the kidney. Two types of epithelial cells, multi-cilia cells and principal cells, are found in the epithelia of the zebrafish distal pronephric duct. While the former is characterized by at

SUBMITTER: Ma M 

PROVIDER: S-EPMC1781496 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature