Comparison of treatment effects between animal experiments and clinical trials: systematic review.

ABSTRACT:

Objective

To examine concordance between treatment effects in animal experiments and clinical trials. Study design Systematic review.

Data sources

Medline, Embase, SIGLE, NTIS, Science Citation Index, CAB, BIOSIS.

Study selection

Animal studies for interventions with unambiguous evidence of a treatment effect (benefit or harm) in clinical trials: head injury, antifibrinolytics in haemorrhage, thrombolysis in acute ischaemic stroke, tirilazad in acute ischaemic stroke, antenatal corticosteroids to prevent neonatal respiratory distress syndrome, and bisphosphonates to treat osteoporosis. Review methods Data were extracted on study design, allocation concealment, number of randomised animals, type of model, intervention, and outcome.

Results

Corticosteroids did no

SUBMITTER: Perel P 

PROVIDER: S-EPMC1781970 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature