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Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA.

ABSTRACT: Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation.

SUBMITTER: Deng GM 

PROVIDER: S-EPMC17824 | biostudies-literature | 2001

REPOSITORIES: biostudies-literature

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Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA.

Deng G M GM   Tarkowski A A  

Arthritis research 20001027 1

Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation. ...[more]