Molecular ablation of ventricular tachycardia after myocardial infarction.

ABSTRACT: Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.

SUBMITTER: Sasano T 

PROVIDER: S-EPMC1783685 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature