An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

ABSTRACT: The cardiac outflow tract develops as a result of a complex interplay among several cell types, including cardiac neural crest cells, endothelial cells, and cardiomyocytes. In both humans and mice, mutations in components of the Notch signaling pathway result in congenital heart disease characterized by cardiac outflow tract defects. However, the specific cell types in which Notch functions during cardiovascular development remain to be defined. In addition, in vitro studies have provided conflicting data regarding the ability of Notch to promote or inhibit smooth muscle differentiation, while the physiological role for Notch in smooth muscle formation during development remains unclear. In this study, we generated mice in which Notch signaling was specifically inactivated in derivatives o

SUBMITTER: High FA 

PROVIDER: S-EPMC1783803 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature