Wnt/beta-catenin signaling is required for development of the exocrine pancreas.

ABSTRACT:

Background

Beta-catenin is an essential mediator of canonical Wnt signaling and a central component of the cadherin-catenin epithelial adhesion complex. Dysregulation of beta-catenin expression has been described in pancreatic neoplasia. Newly published studies have suggested that beta-catenin is critical for normal pancreatic development although these reports reached somewhat different conclusions. In addition, the molecular mechanisms by which loss of beta-catenin affects pancreas development are not well understood. The goals of this study then were; 1] to further investigate the role of beta-catenin in pancreatic development using a conditional knockout approach and 2] to identify possible mechanisms by which loss of beta-catenin disrupts pancreatic development. A Pdx1-cre mou

SUBMITTER: Wells JM 

PROVIDER: S-EPMC1783845 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature