Comparative genomic analysis of the family Iridoviridae: re-annotating and defining the core set of iridovirus genes.

ABSTRACT:

Background

Members of the family Iridoviridae can cause severe diseases resulting in significant economic and environmental losses. Very little is known about how iridoviruses cause disease in their host. In the present study, we describe the re-analysis of the Iridoviridae family of complex DNA viruses using a variety of comparative genomic tools to yield a greater consensus among the annotated sequences of its members.

Results

A series of genomic sequence comparisons were made among, and between the Ranavirus and Megalocytivirus genera in order to identify novel conserved ORFs. Of these two genera, the Megalocytivirus genomes required the greatest number of altered annotations. Prior to our re-analysis, the Megalocytivirus species orange-spotted grouper iridovirus and rock

SUBMITTER: Eaton HE 

PROVIDER: S-EPMC1783846 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature