Multipoint linkage-disequilibrium mapping with haplotype-block structure.

ABSTRACT: The HapMap Project is providing a great deal of new information on high-resolution haplotype structure in various human populations. This information has the potential to greatly increase the power of association mapping for a fixed amount of genotyping. A number of methods have been proposed for the identification of haplotype blocks, common haplotypes, and tagging single-nucleotide polymorphisms. Here, we build on this work by developing novel methods for case-control multipoint linkage-disequilibrium (LD) mapping that gain power and speed by making explicit use of the inferred block structure. Specifically, we developed a virtual-variant approach that uses the haplotype-block information to greatly increase power for detection of untyped common variants associated with a trait. Because

SUBMITTER: Zheng M 

PROVIDER: S-EPMC1785316 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature