Improved power by use of a weighted score test for linkage disequilibrium mapping.

ABSTRACT: Association studies offer an exciting approach to finding underlying genetic variants of complex human diseases. However, identification of genetic variants still includes difficult challenges, and it is important to develop powerful new statistical methods. Currently, association methods may depend on single-locus analysis--that is, analysis of the association of one locus, which is typically a single-nucleotide polymorphism (SNP), at a time--or on multilocus analysis, in which multiple SNPs are used to allow extraction of maximum information about linkage disequilibrium (LD). It has been shown that single-locus analysis may have low power because a single SNP often has limited LD information. Multilocus analysis, which is more informative, can be performed on the basis of either haplotyp

SUBMITTER: Wang T 

PROVIDER: S-EPMC1785334 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature