Multiple genes for essential-hypertension susceptibility on chromosome 1q.

ABSTRACT: Essential hypertension, defined as elevated levels of blood pressure (BP) without any obvious cause, is a major risk factor for coronary heart disease, stroke, and renal disease. BP levels and susceptibility to development of essential hypertension are partially determined by genetic factors that are poorly understood. Similar to other efforts to understand complex, non-Mendelian phenotypes, genetic dissection of hypertension-related traits employs genomewide linkage analyses of families and association studies of patient cohorts, to uncover rare and common disease alleles, respectively. Family-based mapping studies of elevated BP cover the large intermediate ground for identification of genes with common variants of significant effect. Our genomewide linkage and candidate-gene-based assoc

SUBMITTER: Chang YP 

PROVIDER: S-EPMC1785356 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature