Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns.

ABSTRACT:

Background

The C. elegans Promoterome is a powerful resource for revealing the regulatory mechanisms by which transcription is controlled pan-genomically. Transcription factors will form the core of any systems biology model of genome control and therefore the promoter activity of Promoterome inserts for C. elegans transcription factor genes was examined, in vivo, with a reporter gene approach.

Results

Transgenic C. elegans strains were generated for 366 transcription factor promoter/gfp reporter gene fusions. GFP distributions were determined, and then summarized with reference to developmental stage and cell type. Reliability of these data was demonstrated by comparison to previously described gene product distributions. A detailed consideration of the results for one C. e

SUBMITTER: Reece-Hoyes JS 

PROVIDER: S-EPMC1785375 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature