The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms.

ABSTRACT:

Background

Dystrophins and dystrobrevins are distantly related proteins with important but poorly understood roles in the function of metazoan muscular and neuronal tissues. Defects in them and their associated proteins cause a range of neuromuscular disorders. Members of this superfamily have been discovered in a relatively serendipitous way; we set out to compile a comprehensive description of dystrophin- and dystrobrevin-related sequences from available metazoan genome sequences, validated in representative organisms by RT-PCR, or acquired de novo from key species.

Results

Features of the superfamily revealed by our survey include: a) Dystrotelin, an entirely novel branch of the superfamily, present in most vertebrates examined. Dystrotelin is expressed in the central ner

SUBMITTER: Jin H 

PROVIDER: S-EPMC1790709 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature