Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape.

ABSTRACT:

Background

Antigen-specific CTL responses are thought to play a central role in containment of HIV-1 infection, but no consistent correlation has been found between the magnitude and/or breadth of response and viral load changes during disease progression.

Methods and findings

We undertook a detailed investigation of longitudinal CTL responses and HIV-1 evolution beginning with primary infection in 11 untreated HLA-A2 positive individuals. A subset of patients developed broad responses, which selected for consensus B epitope variants in Gag, Pol, and Nef, suggesting CTL-induced adaptation of HIV-1 at the population level. The patients who developed viral escape mutations and broad autologous CTL responses over time had a significantly higher increase in viral load during the

SUBMITTER: Karlsson AC 

PROVIDER: S-EPMC1790860 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature