TICdb: a collection of gene-mapped translocation breakpoints in cancer.

ABSTRACT:

Background

Despite the importance of chromosomal translocations in the initiation and/or progression of cancer, a comprehensive catalog of translocation breakpoints in which these are precisely located on the reference sequence of the human genome is not available at present.

Description

We have created a database that describes the genomic location of 1,225 translocation breakpoints in human tumors, corresponding to 247 different genes, using information from publicly available sources. Junction sequences from reciprocal translocations were obtained from 655 different references (either from the literature or from nucleotide databases), and were mapped onto the reference sequence of the human genome using BLAST. All translocation breakpoints were thus referred to precise nu

SUBMITTER: Novo FJ 

PROVIDER: S-EPMC1794234 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature