Mitochondrial DNA sequence variants in epithelial ovarian tumor subtypes and stages.

ABSTRACT:

Background

A majority of primary ovarian neoplasms arise from cell surface epithelium of the ovaries. Although old age and a positive family history are associated risk factors, the etiology of the epithelial ovarian tumors is not completely understood. Additionally, knowledge of factors involved in the histogenesis of the various subtypes of this tumor as well as those factors that promote progression to advanced stages of ovarian malignancy are largely unknown. Current evidence suggests that mitochondrial alterations involved in cellular signaling pathways may be associated with tumorigenesis.

Methods

In this study, we determined the presence of polymorphisms and other sequence variants of mitochondrial DNA (mtDNA) in 102 epithelial ovarian tumors including 10 matched norm

SUBMITTER: Aikhionbare FO 

PROVIDER: S-EPMC1794240 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature