Mandatory chromosomal segment balance in aneuploid tumor cells.

ABSTRACT:

Background

Euploid chromosome balance is vitally important for normal development, but is profoundly changed in many tumors. Is each tumor dependent on its own structurally and numerically changed chromosome complement that has evolved during its development and progression? We have previously shown that normal chromosome 3 transfer into the KH39 renal cell carcinoma line and into the Hone1 nasopharyngeal carcinoma line inhibited their tumorigenicity. The aim of the present study was to distinguish between a qualitative and a quantitative model of this suppression. According to the former, a damaged or deleted tumor suppressor gene would be restored by the transfer of a normal chromosome. If so, suppression would be released only when the corresponding sequences of the exogenous no

SUBMITTER: Kost-Alimova M 

PROVIDER: S-EPMC1794251 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature