Multiple independent evolutionary solutions to core histone gene regulation.

ABSTRACT:

Background

Core histone genes are periodically expressed along the cell cycle and peak during S phase. Core histone gene expression is deeply evolutionarily conserved from the yeast Saccharomyces cerevisiae to human.

Results

We evaluated the evolutionary dynamics of the specific regulatory mechanisms that give rise to the conserved histone regulatory phenotype. In contrast to the conservation of core histone gene expression patterns, the core histone regulatory machinery is highly divergent between species. There has been substantial evolutionary turnover of cis-regulatory sequence motifs along with the transcription factors that bind them. The regulatory mechanisms employed by members of the four core histone families are more similar within species than within gene familie

SUBMITTER: Marino-Ramirez L 

PROVIDER: S-EPMC1794435 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature